The answer to this question is not cut and dry. What are cannabinoids? – it depends on where the molecules originate from.
Are they produced in the human body or the body of animals? Well, in this case they would be referred to as endocannabinoids, a diverse group of compounds that act upon the CB1 and CB2 receptors of our endocannabinoid system.
Are they produced in the marijuana plant C. Sativa? Well, in this case they would be referred to as phytocannabinoid acids, an equally diverse group of compounds which approximate the molecular structure of the endocannabinoids we produce naturally. When decarboxylated, these plant-derived compounds become bioavailable and can form bonds with our receptors.
There are even exocannabinoids – not just those specific to the marijuana plant, which are receptor agonists or antagonists originating outside our body, but can still interact with the receptors of our endocannabinoid system.
Finally, there are synthetic cannabinoids such as K2, manufactured in a lab, which interact with our endocannabinoid receptors, and like all other cannabinoids, modulate neurotransmission in the brain.
How much is 50ng/ml of Cannabinoids?
A nanogram is expressed 10-9 grams, which is 1 billionth of a gram. So, 50ng/ml can be expressed as 50 billionths of a gram per millilitre. This level of cannabinoid concentration in systemic circulation can be achieved with a relatively small quantity of marijuana. 1 or 2 puffs of a joint should do the trick.
For infrequent users, cannabinoids and their metabolites could be detected with urine testing for 3-5 days after ingestion, whereas moderate and daily users could test hot anywhere from 5-15 days, and chronic heavy users for 30 days or more. The effects of cannabis are cumulative in the body which means the more you use them, the more the effects keep compounding.
Your baseline tolerance for cannabinoids will increase with time and you will require consistently higher doses to achieve comparable effects.
When it comes to cannabinoids, less is more. Like any drug, after a certain point, ingesting more of it has diminishing returns and side-effects.
What is Cannabinoid Hyperemesis Syndrome?
CHS isn’t fully understood, but it is an observable phenomena characterized by vomiting, nausea, and abdominal cramping. The pathophysiology hasn’t been determined but one of the more likely explanations for CHS is the effect cannabis has on gastric motility, gastric emptying, inflammation, inhibition of gastric acid secretion, visceral pain, and altered intestinal motility.
When used for prolonged periods and in high doses, cannabinoids can have a negative impact on these mechanisms which can bring about the symptoms associated with CHS. Irrespective of what the cause is, amelioration of symptoms is achieved by ceasing cannabis use.
Use cannabis in moderation, if for no other reason than to avoid cannabinoid hyperemesis syndrome, or “greening out”.
If you’re a habitual user, taking a break from toking is in your best interest. This isn’t some conspiracy to take your precious weed away, its actually a good rule of thumb for managing long-term use of cannabinoids.